Introduction: What they say
A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”, by Prof. Jung YK, Pyo Jo and others.
Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of of ATG5 (Autophagy-related 5) in the regulation of autophagy.
What we say:
On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Ursolic acid, Diindolylmethane (3,3′-DIM, DIM) and Cholecalciferol (UDMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5)
From research findings to therapeutic opportunity:
This study suggests, for the first time, that a therapeutic mix encompassing Ursolic acid, Diindolylmethane (3,3′-DIM, DIM) and Vitamin-D/Cholecalciferol (UDMC), by increasing the expression of its target genes, it may increase the expression of ATG5. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features (Fig.1).
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Figure1. Mechanistic insights into how a therapeutic mix encompassing Ursolic acid, DIM, and Vitamin-D (UDMC) functions as a longevity promoting agent. The therapeutic mix, as stated above, increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity.
Thus, pharmacological formulations encompassing ” Ursolic acid, Diindolylmethane (DIM) and Vitamin-D/Cholecalciferol or their analogues, either alone or in combination with other longevity-promoting drugs” may be used to increase the lifespan of an individual (Fig.1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan PhD
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# Research cooperation
Undisclosed mechanistic information: How a therapeutic mix encompassing Ursolic acid, Diindolylmethane (3,3′-DIM, DIM) and Vitamin-D increases the expression of ATG5?
References:
Web: http://genomediscovery.org or newbioideas.com/
To cite: Boominathan, L., Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Ursolic acid, Diindolylmethane (3,3′-DIM, DIM) and Cholecalciferol (UDMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 18/September/2017, 11.04 pm
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