Spread the love

National Science day special

*********

We wish every one a very happy National Science day. On this special occasion, we are happy to announce that ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today (28/February/2017). Each idea posted will be served first come, first served basis.Write to info@genomediscovery.org for more details. 

Dr L Boominathan PhD

President & CSO, GBMD.

************************************************************************************

 

From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

A number of studies suggest that Naringenin functions as an anticancer agent. However, the mechanism of action is far from clear.

This study suggests that Naringenin, by increasing the expression of its target genes, it may decrease the expression of metastasis promoter PMP22 (fig. 1).

Naringenin inhibits metastasis suppressor PMP22
Fig1. Mechanistic insights into how Naringenin functions as an anti-metastasis agent. It functions as an antimetastatic agent by decreasing the expression of PMP22

Thereby, it may inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Naringenin or its analogues either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed mechanistic information: How Naringenin decreases the expression of metastasis promoter PMP22


References

CitationBoominathan, L., Natural product-derived therapy for Metastatic cancers: Naringenin, a flavonoid found in grapefruit, oranges, and tomatoes (skin) among others, decreases the expression of PMP22 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 6.46 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org


Spread the love