What is known?
I have published earlier that Amla extract: (i) increases the levels of tumor suppressor p53, inhibits the proliferation of tumor-initiating cells in breast cancer, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients; and (ii) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression.
From Research findings to Therapeutic opportunity:
The study presented here suggests that Amla extract, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decreases BMI1 translocation; (iii) increases tumor suppressor INK4a/p16 expression; and (iv) restores chemosensitivity in drug-resistant Human cancers.
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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Amla extract or an active compound isolated from Amla extract or Amla extract in combination with other anticancer drugs” may be used to inhibit cancer progression.
Figure 1 Emblica Officianalis (Amla). Amla extract increases the expression of CADM1, inhibits BMI-1 translocation, increases tumor suppressor INK4a/p16 expression and inhibits chemoresistance via up-regulation of its target gene
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How Amla extract increases the expression of CADM1, and INK4a/p16?
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References:
Citation: Boominathan, L., Natural product-derived therapy for overcoming chemoresistance in Human cancers: Amla extract increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 10/December/2016, 8.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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