What they say: Introduction:
A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 October 2016 issue of the Journal “Cell Reports” by Prof David J. Picketts, Dr. Matías Alvarez-Saavedra and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product-derived therapy for brain repair and Lifespan extension: Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa and Artemisia douglassiana Besser, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene
From Research Findings to Therapeutic opportunity:
This study suggests a natural product-based therapy for brain repair and lifespan extension.
Dehydroleucodine, by increasing the expression of its target gene, it may increase the expression of VGF and BDNF (fig1). Thereby, it may: 1) promote OP proliferation, 2) trigger myelination on neurons, 3) revert neural damage, 4) confer protection against brain ischemia, 5) promote consolidation of hippocampal memory, 6) produce antidepressant like effects, 7) enhance glucose-stimulated insulin secretion, 8) decrease stress hormones norepinephrine and epinephrine levels and blood pressure, and finally, as a consequence, 9) prolong lifespan
Figure 1. Gynoxys. Dehydroleucodine, found in Gynoxys, promotes brain repair and extends mammalian lifespan via up-regulation of VGF and BDNF
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Figure 2. Artemisia douglasiana Besser. Dehydroleucodine can also be found in Artemisia douglasiana.
Figure 3. Dehydroleucodine increases VGF and BDNF expression to promote brain repair and extend life-span
Thus, pharmacological formulations encompassing “Dehydroleucodine or its analogs or Dehydroleucodine plus any of the known compounds that promote longevity“ can be used to promote brain repair, treat neurodegenerative diseases (such as multiple sclerosis), and extend the lifespan of an individual (fig 3).
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed Information: How Dehydroleucodine increases the expression of VGF and BDNF and promotes brain repair and mammalian life-span?
# Research cooperation
Amount: $300 #
References:
Citation: Boominathan, L., Natural product-derived therapy for brain repair and Lifespan extension: Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa and Artemisia douglassiana Besser, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 9/December/2016, 10.34 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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