What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1.
What is known?
I have recently shown that 2,4,5-trihydroxybenzaldehyde (TDB): (1) increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes; and (2) decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. 2,4,5-trihydroxybenzaldehyde (TDB), by increasing the expression of its target gene, it may increase the expression of BuBR1.
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Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “2,4,5-trihydroxybenzaldehyde (TDB) or TDB plus any of the known longevity promoting drug (s)” may be used to extend the lifespan of an individual.
Figure1. Geum japonicum flower. 2,4,5-trihydroxybenzaldehyde (TDB), isolated from Geum japonicum , extends mammalian life span via up regulation of BuBR1
Figure2. Polygonum cuspidatum. TDB, which is also found in Polygonum cuspidatum, aids in lifespan extension
Fig 3. TDB functions as a longevity promoter via up regulation of a number of longevity-promoting genes, including BuBR1
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed mechanistic information: How 2,4,5-trihydroxybenzaldehyde (TDB) increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
Reference:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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