From Research findings to Therapeutic opportunity:
The study presented here suggests that Rhamnetin, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decreases BMI1 translocation; (iii) increases tumor suppressor INK4a/p16 expression; and (iv) restores chemosensitivity in drug-resistant Human cancers.
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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Rhamnetin or its analogues or Rhamnetin in combination with any of known anti-cancer drugs” may be used to inhibit cancer progression.
Figure 1 Rhamnetin, found in Cloves, increases the expression of CADM1, inhibits BMI-1 translocation, increases tumor suppressor INK4a/p16 expression and inhibits chemoresistance via up-regulation of its target gene
Figure 2. Cloves
Figure 3. Rhamnetin
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How Rhametin increases the expression of CADM1, and INK4a/p16?
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References:
Citation: Boominathan, L., Natural product-derived therapy for overcoming chemoresistance in Human cancers: Rhamnetin, found in cloves, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 9/December/2016, 10.07 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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