A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September 2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71] by Prof Daley GQ, Zhu H, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Apple extract promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28
Significance:
Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.
Prof. Daley GQ and his team members had shown that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance.
Apple tree. Apple extract promotes insulin sensitivity via up-regulation of reprogramming protein Lin-28B
This study suggests, for the first time, that Apple extract, by increasing the expression of its target gene, it may increase the expression of RNA-binding protein Lin-28. Thereby, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote youthful regenerative capacity; and (4) promote insulin sensitivity. Thus, pharmacological formulations encompassing “Apple extract or a pharmacologically active compound isolated from it” may be used to treat DM.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan L, Natural product therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Apple extract promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 14/Oc tober/2016, 9.47 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Apple extract increases the expression of Lin28
Amount: $300
Results guaranteed if not refunded
# Research cooperation