Optimal sleep is required to lead a diabetics-free life: Melatonin-based therapy for diabetes (TIIDM): Melatonin [N-acetyl-5-methoxy tryptamine], a hormone that regulates sleep and wakefulness, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 13/June/2018, 8.29 am