Probiotic-based therapy for pulmonary arterial hypertension (PAH): Bifidobacterium lactis LKM512-containing yogurt inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 17/November/2018, 12.11 am

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What they say: 

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054],  by Prof. Thistlethwaite PA, Li X and others.

What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:

Probiotic-based therapy for pulmonary arterial hypertension (PAH): Bifidobacterium lactis LKM512-containing yogurt inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3

The significance of the study:  

This study suggests, for the first time, that Bifidobacterium lactis LKM512, by increasing the expression of its target gene, it may decrease, in a dose-dependent manner, the expression of Notch3 and its target gene Hes-5 (Fig.1). Thereby, it may inhibit and promote, respectively, proliferation and differentiation of smooth muscle cells. And, thereby, prevent pulmonary hypertension (Figure 1).  Thus, pharmacological formulations encompassing “Bifidobacterium lactis LKM512, either alone or in combination with other drugs,” may be used to treat pulmonary arterial hypertension (Figure 2).

Figure 1. Mechanistic insights into how Probiotic Bifidobacterium lactis LKM512 inhibits the development of pulmonary hypertension through regulation of its target genes
Figure 1. Mechanistic insights into how Probiotic Bifidobacterium lactis LKM512 inhibits the development of pulmonary hypertension through regulation of its target genes

Details of the research findings: 

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Undisclosed mechanistic information: How does Bifidobacterium lactis LKM512-containing yogurt decrease the expression of Notch3 and its target gene?

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References: 

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Citation: Boominathan, L.,  Probiotic-based therapy for pulmonary arterial hypertension (PAH): Bifidobacterium lactis LKM512-containing yogurt inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 17/November/2018, 12.10 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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