What we say:
Dr L Boominathan PhD, Director-
cum-chief Scientist of GBMD, reports that: Roxithromycin increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene.
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From Significance of the study to Public health relevance:
Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.
From Research findings to Therapeutic opportunity:
This study provides, for the first time, mechanistic insights into how the antibiotic Roxithromycin may aid in the treatment of HIV infection.
Roxithromycin, by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses.
Figure 1 Mechanistic insights into how Roxithromycin functions as an anti-HIV agent. Carnosol inhibits HIV-1 budding and production via up-regulation of its target gene HO-2
Thus, pharmacological formulations encompassing “Roxithromycin or its analogs, either alone or in combination with other drugs,” may be used to inhibit HIV-1 production.
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Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Roxithromycin increase the expression of Heme oxygenase-2 (HO-2)?
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com/
Citation: Boominathan, L., Antiviral therapy for HIV virus: Roxithromycin increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 12/October/2017, 11.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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