Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Xylitol, by increasing the expression of its target genes, it may decrease the expression of AT1R.
Figure1. Mechanistic insights into how Xylitol functions as a longevity-promoter. Xylitol, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity
Figure 2. The chemical structure of Xylitol. Xylitol can be isolated from corn and raspberry.
And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Xylitol or its analogues, either alone or in combination with other anti-ageing/longevity promoting compounds,“ may be used to extend the lifespan of an individual (Figures 1-2).
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Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Xylitol suppress the expression of angiotensin II type I receptor (AT1R)?
Amount: $300
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# Research cooperation
References:
Citation: Boominathan, L., A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener found in drugs, confections, toothpaste, and chewing gum, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 23/March/2018, 12.25 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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