Sugar-based therapy for diabetes (TIIDM): Lactulose (brand name: Cholac, Generlac, Consulose, Duphalac), a drug used in the treatment of constipation and hepatic encephalopathy, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 27/March/2018, 5.50 am