The tiny probiotic Lactobacillus acidophilus may function as a Pain medication:  Probiotic Lactobacillus acidophilus increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 20/November/2018, 11.42 pm