What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Lengthening the lifespan of mighty humans with tiny probiotics: Probiotic Lactobacillus Salivarius LA307-based lifespan extension therapy: Lactobacillus Salivarius LA307 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes
Research findings to Therapeutic opportunity:
Probiotics have been shown to exert a number of therapeutic properties, but the mechanism of action remains largely unclear.
Figure 1. Mechanistic insight into how Probiotic Lactobacillus Salivarius LA307 may extend lifespan. Probiotic Bacillus licheniformis inhibits p70 S6 kInase expression and promotes longevity
Figure 2. Probiotic Lactobacillus Salivarius LA307 functions as a longevity-promoter
This study suggests, for the first time, that Probiotic Lactobacillus Salivarius LA307, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
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Thus, pharmacological formulations encompassing “Lactobacillus Salivarius LA307, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Lactobacillus Salivarius LA307 decrease the expression of p70 S6 Kinase and promotes mammalian lifespan?
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References:
Citation: Boominathan, L., Lengthening the lifespan of mighty humans with tiny probiotics: Probiotic Lactobacillus Salivarius LA307-based lifespan extension therapy: Lactobacillus Salivarius LA307 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes, 26/September/2018, 7.34 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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