Treating anxiety and depression with blood sugar disease drug Metformin:  Metformin, the widely used drug in the treatment of TIIDM, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down regulation of its target gene, 9/May/2018, 9.55 pm