Unknown function of the known steroid hormone in targeting cancer stem cells in Myeloid leukaemia (ML): Progesterone (P4), a steroid hormone, inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 18/August/2017, 12.31 am