What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: The contraceptive/birth control pill component Progestin may extend lifespan and healthspan: Progestin, one of the components of contraceptives and birth control pills, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene
Research findings to Therapeutic opportunity:
Progestin, a component of birth control/contraceptive pills, has also been shown to aid in the treatment of other gynecological conditions.
This study suggests, for the first time, that Progestin, by increasing the expression of its target gene, it may suppress ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote (1) resistance to the bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Figure 1. Mechanistic insight into how Progestin may extend lifespan. Progestin inhibits p70 S6 kinase expression and increases the expression of other longevity- promoting genes.
Figure 2. The chemical structure of Progestin. Progestin functions as a longevity promoting agent through down-regulation of p70S6 kinase
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Thus, pharmacological formulations encompassing “Progestin or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (fig. 2).
Given the mechanistic basis of how Progestin may function as a longevity-promoting agent, obstetricians and gynecologists and general practitioners may consider: encouraging their needy patients to take Progestin or beginning a clinical trial.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How progestin decreases the expression of p70 S6 Kinase and promotes mammalian lifespan
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References:
Citation: Boominathan, L., The contraceptive/birth control pill component Progestin may extend lifespan and healthspan: Progestin, one of the components of contraceptives and birth control pills, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 18/August/2017, 12.14 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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