Introduction: What they say
A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.” This research paper was published, in the 10 August 2016 issue of the journal “Cell Host and microbe” [One of the best research journals in Infectious biology with an I.F of 12.552], by Prof. Marco Vignuzzi, Bryan C. Mounce and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Where eating the peel will protect you against viral diseases than the pulp (fruit): Citrus peel-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Hesperidin, Tangeretin & Nobiletin (HTN), isolated from citrus flavonoid purity mixture or citrus peels, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene
What is known?
Prof. Marco Vignuzzi’s research team has recently shown that induction of type I interferon results in: a) upregulation of SAT1; b) depletion of spermidine and spermine levels; and c) inhibition of Chikungunya and Zika viruses production. They have further validated this by showing that exogenous administration of Polyamines (spermidine and spermine) restores virus replication.
From research findings to Therapeutic opportunity:
This study suggests a Citrus peels-based antiviral therapy for RNA viruses, such as Chikungunya virus (CHIKV) and Zika virus (ZIKV). Hesperidin, Tangeretin & Nobiletin (HTN), isolated from citrus peel or citrus flavonoid purity mixture, may attenuate the replication of CHIKV and ZIKV.
A pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN), by decreasing the expression of its target gene, it may increase the expression of spermidine/spermine N1-acetyltransferase (SAT1) (Figure 1). Thereby, it may: (1) decrease polyamine spermidine and spermine levels; (2) stall CHIKV and ZIKV replication; (3) promote clearance of Zika and Chikungunya Viruses; and (4) strengthen antiviral immunity against RNA viruses. (Figure 2)
Figure 1 Mechanistic insights into how Hesperidin, Tangeretin & Nobiletin (HTN), derived from citrus flavonoid purity mixture, functions as an antiviral agent. HTN inhibits the replication of Chikungunya and Zika viruses through induction of SAT
Figure 2. HTN functions as an anti-CHIKV/ZIKV agent
Figure 3. While polyamine (PA) depletion inhibits the replication of chikungunya and Zika virus replication, the study presented suggests for the first time that a pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN) attenuates chikungunya and Zika virus replication,
Thus, pharmacological formulations encompassing “Hesperidin, Tangeretin & Nobiletin (HTN) or their analogs, either alone or in combination with other drugs”, may be used to treat infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses. Given that natural product-derived compound HTN is more safe, and economical compared with chemicals-based antiviral therapy, it may find larger utility in patient care as a side-effective free and cost-effective and more potent antiviral agent.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Hesperidin, Tangeretin & Nobiletin (HTN) decrease the expression of spermidine/spermine N1-acetyltransferase (SAT1)?
Amount: $ 500#
For payment and purchase details, you may reach us at admin@genomediscovery.org
# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L, Where eating the peel will protect you against viral diseases than the pulp (fruit): Citrus peel-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Hesperidin, Tangeretin & Nobiletin (HTN), isolated from citrus flavonoid purity mixture or citrus peels, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 17/July/2019, 10.45 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite, drop us a line at admin@genomediscovery.org