Assigning an unknown function to a known female reproductive hormone Estrogen in Longevity: Estrogen-based therapy for aging-associated diseases and Lifespan extension: Estrogen, a female steroid hormone, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 10/August/2018, 10.41 am