What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Estrogen functions as a longevity promoter: Estrogen, a female steroid hormone, may increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, that Estrogen, by increasing the expression of its target gene, may: (a) increase the expression of BuBR1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase); (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).
Figure 1. Estrogen functions as a longevity promoter. Astragalus polysaccharide may extend mammalian lifespan via up-regulation of BuBR1; and down-regulation of p70 S6 Kinase
Figure 2. The chemical structure of Estrogen. Estrogen functions as a longevity-promoter through induction of BuBR1.
Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median lifespan. Thus, estrogen or its analogs, either alone or in combination with other drugs,“ may be used to extend the lifespan of an individual (fig.2). Finally, this study provides mechanistic insights into, yet another reason as to, why women outlive men.
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Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.
Amount: $75
0#
Undisclosed mechanistic information: How Estrogen increases the expression of BubR1 and extend mammalian life-span
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References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Estrogen functions as a longevity promoter: Estrogen, a female steroid hormone, may increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 10/August/2018, 10.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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