Ideas

June 19, 2018

Published by admin_auro at June 19, 2018

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Combinatorial therapy targeting PD-L1 pathway enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing Lovastatin, Lofepiramine, AUY922, Temozolomide, Salinomycin, 5-Fluro-2’deoxycytidine (LLATSF) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 19/June/2018, 10.24 pm

Introduction:What they say: A recent study from Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California, USA; Jonsson Comprehensive Cancer […]

June 16, 2018

Published by admin_auro at June 16, 2018

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Cancer
Ideas

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Sitagliptin (trade name: Januvia), a DPP4 inhibitor, increases the expression of tumor suppressors genes, such as p53, TA-p73 and TA-p63, BTG2 and INK4a, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 16/June/2017, 11.48 pm

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

June 16, 2018

Published by admin_auro at June 16, 2018

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The miracle herb Holy basil (Tulsi) may help you live longer: Ursolic acid-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (UCIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 16/June/2018, 11.30 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]

June 16, 2018

Published by admin_auro at June 16, 2018

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Natural product-derived therapy for cardiac hypertrophy and fibrosis: A pharmaceutical mixture encompassing βCryptoxanthin, Mangiferin & Glycyrrhetinic acid (CMG) decreases MiR-29 expression, activates wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1 and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via up regulation of its target gene, 16/June/2017, 7.07 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]