Ideas

April 14, 2018
Published by admin_auro at April 14, 2018
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Treating pain with Endorphins: Endorphin-based activation of the PD-1 pathway for Pain therapy: β-Endorphin, an endogenous opioid neuropeptide and peptide hormone known to play a role in hunger, thrill, pain, maternal care, reward, and cognition, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 14/April/2018, 11.47 pm

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
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April 14, 2018
Published by admin_auro at April 14, 2018
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A sweet way to say no to blood sugar disease: Sugar-based therapy for TIIDM: D-Mannose, a C-2 epimer of glucose,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 14/April/2018, 11.28 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
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April 14, 2018
Published by admin_auro at April 14, 2018
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Bonding your way to extend your lifespan and healthspan: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, may increase life span, via up-regulation of its target gene BubR1 and others, 14/April/2018, 11.16 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and […]
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April 14, 2018
Published by admin_auro at April 14, 2018
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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 14/April/2017, 6.40 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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