Ideas

June 16, 2017

Mechanical stretch therapy for Diabetic nephropathy (DN): Mechanical stretch therapy increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 17/June/2017, 12.03 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may […]
June 16, 2017

Molecular therapy for middle aged TIIDM patients: Metformin, the widely used drug in the treatment of TIIDM, decreases DNA-PPK expression, suppresses phosphorylation of HSP90a, increases AMPK activity, augments mitochondrial biogenesis and energy metabolism, promotes weight loss and exercise endurance and alleviates TIIDM via down regulation of its target gene, 17/June/2017, 12.00 pm

Introduction: What they say A study from the Laboratory of Obesity and Aging Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD […]
June 16, 2017

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Zinc finger protein SNAI1 (Snail family transcriptional repressor 1), the epithelial to mesenchymal transition regulator, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene, 16/June/2017, 11.59 pm

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The […]
June 15, 2017

Combination therapy for enhancing the efficacy of tyrosine-kinase inhibitor (TKI) in BCR-ABL-induced Human leukemia: A therapeutic mix encompassing Ascorbate and Forodesine decreases the expression of oncoproteins c-FOS, DUSP1 and BCR-ABL, inhibits TKI resistance, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and cure CML and kinase-driven cancers via up-regulation of its target gene, 16/June/2017, 2.05 am

Introduction: What they say: A study from the Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA; Division of Pathology, Cincinnati Children’s Hospital […]
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