Ideas

Natural product-derived therapy for overcoming chemoresistance in Human cancers: Rhamnetin, found in cloves, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 9/December/2016, 10.07 pm
Natural product-derived therapy for overcoming chemoresistance in Human cancers: Rhamnetin, found in cloves, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 9/December/2016, 10.07 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Rhamnetin, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decreases BMI1 translocation; (iii)…

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Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am
Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am 150 150 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-486 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, and SPRY1/2 and induces regression of p53-mutated human tumors via down regulation of its target gene, 9/December/2016, 10.53 am
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-486 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, and SPRY1/2 and induces regression of p53-mutated human tumors via down regulation of its target gene, 9/December/2016, 10.53 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived therapy for Myocardial Infarction: Saponin, found in Panx Japonicus and Soapworts among others, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 9/December/2016, 8.13 am
Natural product-derived therapy for Myocardial Infarction: Saponin, found in Panx Japonicus and Soapworts among others, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 9/December/2016, 8.13 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Anti-telomerase cancer therapy: MiRNA-362 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 9/December/2016, 6.18 am
Anti-telomerase cancer therapy: MiRNA-362 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 9/December/2016, 6.18 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product-derived therapy for brain repair and Lifespan extension: Casticin, found in Vitex agnus-castus, and Artemisia annua, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 8/December/2016, 11.58 pm
Natural product-derived therapy for brain repair and Lifespan extension: Casticin, found in Vitex agnus-castus, and Artemisia annua, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 8/December/2016, 11.58 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue,…

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