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Ideas

March 13, 2017

Natural product-derived therapy for metastatic prostate cancer: (-)-Epigallocatechin, isolated from Green tea, inhibits the expression of CDC42, CDC42EP3, RAC1 and ARPC5, and GAS6, suppresses the expression of stem cell molecules CD44 and EZH2, promotes epithelial phenotype, suppresses tumorigenesis, migration, invasion, stem cell regeneration and metastasis via up regulation of its target gene, 13/March/2017, 5.11 pm

Introduction: What they say: A study from the Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park, Texas 78957, USA […]
March 13, 2017

Life-extension therapy: Carvedilol, a nonselective beta blocker/alpha-1 blocker used in the treatment of congestive heart failure and left ventricular dysfunction, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/March/2017, 8.24 am

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
March 13, 2017

Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: Fisetin, a flavanol isolated from strawberries, apples, persimmons, onions, cucumbers, and acacias among others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 13/March/2017, 7.00 am

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that […]
March 12, 2017

Cardiac rejuvenation therapy: Gambogic acid, derived from Garcinia hanburyi, suppresses tumor suppressor INK4a/p16 expression, inhibits dilated cardiomyopathy and heart failure and extends life span via up regulation of its target gene, 13/March/2017, 12.08 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated […]
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