Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: N(1), N(11)-Diethylnorspermine (DENSPM), a spermine analog, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 8/December/2016, 11.31 pm
Natural product-derived PD-1 pathway blockade for Human cancer therapy: N(1), N(11)-Diethylnorspermine (DENSPM), a spermine analog, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 8/December/2016, 11.31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Natural product-derived anti-ageing therapy: Saponin, found in Panax japonicus and Soapwort, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 8/December/2016, 11.04 pm
Natural product-derived anti-ageing therapy: Saponin, found in Panax japonicus and Soapwort, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 8/December/2016, 11.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental…

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Natural product-derived Cardioprotective therapy: Saponins, isolated from Panax japonicus, increase Spermidine levels, augment autophagy, mitophagy and mitochondrial respiration, lower systemic blood pressure, and protect from cardiac diseases via down regulation of their target genes, 8/December/2016, 10.45 pm
Natural product-derived Cardioprotective therapy: Saponins, isolated from Panax japonicus, increase Spermidine levels, augment autophagy, mitophagy and mitochondrial respiration, lower systemic blood pressure, and protect from cardiac diseases via down regulation of their target genes, 8/December/2016, 10.45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.”…

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Cardiac rejuvenation therapy: Leucine, an essential amino acid, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 7/December/2016, 11.37 pm
Cardiac rejuvenation therapy: Leucine, an essential amino acid, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 7/December/2016, 11.37 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Natural product-derived therapy for Cardiomyopathy: Panax japonicus induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 7/December/2016, 11.16 pm
Natural product-derived therapy for Cardiomyopathy: Panax japonicus induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 7/December/2016, 11.16 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp…

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Natural product-derived cardioprotective therapy: Icarrin, isolated from Horny-goat-weed, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 7/December/2016, 10.42 pm
Natural product-derived cardioprotective therapy: Icarrin, isolated from Horny-goat-weed, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 7/December/2016, 10.42 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.”…

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