Ideas

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Ganoderma lucidum extract decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 7/December/2016, 10.27 pm
Natural product-derived PD-1 pathway blockade for Human cancer therapy: Ganoderma lucidum extract decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 7/December/2016, 10.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Natural product-derived therapy for Myocardial Infarction: Kavalactone (2′,6′-dichloro-5-methoxymethyl-5,6-dehydrokawain), found in herb kava kava, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS , 7/December/2016, 11.18 am
Natural product-derived therapy for Myocardial Infarction: Kavalactone (2′,6′-dichloro-5-methoxymethyl-5,6-dehydrokawain), found in herb kava kava, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS , 7/December/2016, 11.18 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Cardiac rejuvenation therapy: MECP2 (Methyl-CpG-binding protein 2), a transcriptional suppressor, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 6/December/2016, 10.02 pm
Cardiac rejuvenation therapy: MECP2 (Methyl-CpG-binding protein 2), a transcriptional suppressor, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 6/December/2016, 10.02 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Natural product-based therapy for Cardiomyopathy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Salicornia herbacea L, and Aster Ohrai among others, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 6/December/2016, 9.53 pm
Natural product-based therapy for Cardiomyopathy: Methyl 3,5-dicaffeoyl quinate (MDQ), found in Salicornia herbacea L, and Aster Ohrai among others, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 6/December/2016, 9.53 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp…

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Natural product-based cardioprotective therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 6/November/2015, 9.39 pm
Natural product-based cardioprotective therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, and protects it from cardiac diseases via down regulation of its target gene, 6/November/2015, 9.39 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.”…

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Molecular therapy for Myocardial Infarction: Amiodarone, a second line agent in the treatment of cardiac arrest, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 6/December/2016, 3.20 pm
Molecular therapy for Myocardial Infarction: Amiodarone, a second line agent in the treatment of cardiac arrest, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 6/December/2016, 3.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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