Ideas

MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-940 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 6/December/2016, 12.46 pm
MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-940 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 6/December/2016, 12.46 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Natural product-based Lifespan extension therapy: Apple extract increases the expression of longevity-promoting and antiaging gene Klotho via up regulation of its target gene, 5/December/2016, 11. 33 pm
Natural product-based Lifespan extension therapy: Apple extract increases the expression of longevity-promoting and antiaging gene Klotho via up regulation of its target gene, 5/December/2016, 11. 33 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What is known? It has been shown earlier that Klotho: (1) extends the lifespan of mice by about 19-31%; and (2) increases cognition.  From Significance of the study to Therapeutic…

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Natural product-derived therapy for brain repair and Lifespan extension: Shikonin, found in Zicao (also known as purple gromwell), increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 5/December/2016, 10.52 pm
Natural product-derived therapy for brain repair and Lifespan extension: Shikonin, found in Zicao (also known as purple gromwell), increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 5/December/2016, 10.52 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue,…

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Natural product Lifespan extension therapy: Areca nut extract or Arecoline increases life span via up-regulation of its target gene BubR1, 05/December/2016, 10.10 pm
Natural product Lifespan extension therapy: Areca nut extract or Arecoline increases life span via up-regulation of its target gene BubR1, 05/December/2016, 10.10 pm 150 150 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Small RNA-based Life-extension therapy: MiR-15/16 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/December/2016, 7.59 pm
Small RNA-based Life-extension therapy: MiR-15/16 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/December/2016, 7.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Natural product-derived Life-span extension therapy: Ginsenoside 20(S)-Rg3, one of the main components of Panax ginseng, activates autophagy and extends lifespan via up regulation of its target gene, 5/December/2016, 7. 31 pm
Natural product-derived Life-span extension therapy: Ginsenoside 20(S)-Rg3, one of the main components of Panax ginseng, activates autophagy and extends lifespan via up regulation of its target gene, 5/December/2016, 7. 31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Ginsenoside 20(S)-Rg3, one of the main components of Panax ginseng, activates autophagy and extends lifespan via up regulation of…

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