MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-940 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 6/December/2016, 12.46 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published in the 16 February 2016 issue […]

Natural product-based Lifespan extension therapy: Apple extract increases the expression of longevity-promoting and antiaging gene Klotho via up regulation of its target gene, 5/December/2016, 11. 33 pm

What is known? It has been shown earlier that Klotho: (1) extends the lifespan of mice by about 19-31%; and (2) increases cognition.  From Significance of the study to Therapeutic opportunity:   This study suggests a natural product-based Life-extension therapy. Apple extract, by increasing the expression of its target genes, it may increase the expression of longevity-promoting and […]

Natural product-derived therapy for brain repair and Lifespan extension: Shikonin, found in Zicao (also known as purple gromwell), increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 5/December/2016, 10.52 pm

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. This study was published in the 11 […]

Natural product Lifespan extension therapy: Areca nut extract or Arecoline increases life span via up-regulation of its target gene BubR1, 05/December/2016, 10.10 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof […]

Small RNA-based Life-extension therapy: MiR-15/16 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/December/2016, 7.59 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What we […]

Natural product-derived Life-span extension therapy: Ginsenoside 20(S)-Rg3, one of the main components of Panax ginseng, activates autophagy and extends lifespan via up regulation of its target gene, 5/December/2016, 7. 31 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Ginsenoside 20(S)-Rg3, one of the main components of Panax ginseng, activates autophagy and extends lifespan via up regulation of its target gene [easy_payment currency=”USD”] From Significance of the study to Therapeutic opportunity: This study suggests, for the first time, that Ginsenoside 20(S)-Rg3, by increasing the […]