MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-192 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 4/December/2016, 9.20 pm

Introduction:What they say:   A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in […]

Molecular therapy for Bone disorders: MiR-185 inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 4/December/2016, 9.01 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, […]

Small molecule-based anti-ageing therapy: Yin Yang 1 (YY1) increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 3/December/2015, 8.01 am

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA shows that Prolonged Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. This […]

Natural product therapy for Bone disorders: Chebulagic acid (CHA), isolated from Terminalia chebula, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 3/December/2016, 7.49 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and others from  the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, […]

Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.57 pm

What they say? A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What we […]

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 3/December/2015, 5.38 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published in the 10 August 2016 issue of the journal […]