Ideas

Natural product-derived therapy for Myocardial Infarction: Guggulsterone (4,17(20)-pregnadiene-3,16-dione), a resin found in the Guggul herb Commiphora mukul, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 3/December/2016, 6.55 am
Natural product-derived therapy for Myocardial Infarction: Guggulsterone (4,17(20)-pregnadiene-3,16-dione), a resin found in the Guggul herb Commiphora mukul, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 3/December/2016, 6.55 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Natural product Life-span extension therapy: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, may increase life span by suppressing mTOR pathway, 2/December/2016, 11.27 pm
Natural product Life-span extension therapy: Ferulic acid, found abundantly in the flax seeds, refined maize bran and soft and hard rice bran among others, may increase life span by suppressing mTOR pathway, 2/December/2016, 11.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What is known:  It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters.” I have published…

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Natural product-derived cardioprotective therapy: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, the main component of Polygonum multiflorum thunb, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, protects it from cardiac diseases and promotes longevity via down regulation of its target gene, 2/December/2016, 7.31 pm
Natural product-derived cardioprotective therapy: 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, the main component of Polygonum multiflorum thunb, increases Spermidine levels, augments autophagy, mitophagy and mitochondrial respiration, lowers systemic blood pressure, protects it from cardiac diseases and promotes longevity via down regulation of its target gene, 2/December/2016, 7.31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, A-8010 Graz shows that “Cardioprotection and lifespan extension by the natural polyamine spermidine.”…

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Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon), activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.14 pm
Natural product-derived anti-ageing therapy: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon), activates autophagy and extend lifespan via up regulation of its target gene, 2/December/2016, 7.14 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Shikonin, the major component of Zicao (also known as purple gromwell, the dried root of Lithospermum erythrorhizon),  activates…

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Natural product-derived therapy for triple-negative breast tumors: Withaferin A, isolated from Withania somnifera/Ashwagandha and Acnistus arborescens among others, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 2/December/2015, 6.32 pm
Natural product-derived therapy for triple-negative breast tumors: Withaferin A, isolated from Withania somnifera/Ashwagandha and Acnistus arborescens among others, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 2/December/2015, 6.32 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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Natural product-derived therapy for Myocardial Infarction: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, and Japanese knotweed among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/December/2016, 12.15 pm
Natural product-derived therapy for Myocardial Infarction: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, and Japanese knotweed among others, inhibits DNA damage responses, and telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 2/December/2016, 12.15 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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