Ideas

Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Eriocitrin, isolated from lemons, increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 28/November/2015, 10.45 pm
Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Eriocitrin, isolated from lemons, increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 28/November/2015, 10.45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Resveratrol suppresses NTHi-induced…

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Molecular therapy for triple-negative breast tumors: BMP4 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 28/November/2015, 7.04 pm
Molecular therapy for triple-negative breast tumors: BMP4 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 28/November/2015, 7.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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Anti-metastasis therapy: Anticancer drug Campothecin (CPT) decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 28/November/2016, 6.55 pm
Anti-metastasis therapy: Anticancer drug Campothecin (CPT) decreases PDPN expression, invasion, migration and metastasis of tumor cells via up regulation of its target gene, 28/November/2016, 6.55 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that Anticancer drug Campothecin (CPT), by increasing the expression of its target genes, it may decrease the expression of oncoprotein PDPN.…

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Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein Fas ligand (FasL) and inhibits proliferation, chemoresistance and apoptosis of cancer cells via down regulation of its target gene, 28/November/2016, 6.46 pm
Anticancer therapy: MiRNA-9600 increases the expression of pro-apoptotic protein Fas ligand (FasL) and inhibits proliferation, chemoresistance and apoptosis of cancer cells via down regulation of its target gene, 28/November/2016, 6.46 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of pro-apoptotic protein Fas Ligand (FasL). [easy_payment currency=”USD”]…

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Molecular therapy for Myocardial Infarction: MiR-301 improves myocardial function after myocardial infarction via up-regulation of PNUTS, 28/November/2016, 12.22 pm
Molecular therapy for Myocardial Infarction: MiR-301 improves myocardial function after myocardial infarction via up-regulation of PNUTS, 28/November/2016, 12.22 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What…

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Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-103 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/November/2016, 6.24 am
Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-103 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/November/2016, 6.24 am 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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