Ideas

Natural product-derived therapy for Intestinal cancer: American Ginseng increases the expression of DNA Sensor AIM2 and inhibits expansion of tumor-initiating intestinal stem cell population via up regulation of its target gene, 29/November/2016, 11.47 pm
Natural product-derived therapy for Intestinal cancer: American Ginseng increases the expression of DNA Sensor AIM2 and inhibits expansion of tumor-initiating intestinal stem cell population via up regulation of its target gene, 29/November/2016, 11.47 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say: Introduction: A recent study from the Department of Immunology, Saint Jude Children’s Research Hospital, Memphis, TN 38105, USA shows that:  “Critical Role for the DNA Sensor AIM2 in…

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MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-3646 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/November/2016, 10.04 pm
MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-3646 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/November/2016, 10.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:   A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression…

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Natural product-derived therapy for tuberculosis: Ganoderma lucidum, a medicinal/herbal mushroom, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 29/November/2016, 8.39 pm
Natural product-derived therapy for tuberculosis: Ganoderma lucidum, a medicinal/herbal mushroom, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 29/November/2016, 8.39 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was…

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Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am
Natural product-derived anti-ageing therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 29/November/2015, 10.10 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental…

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Molecular therapy for Myocardial Infarction: PPARδ improves myocardial function after myocardial infarction via up-regulation of PNUTS, 29/November/2016, 6.00 am
Molecular therapy for Myocardial Infarction: PPARδ improves myocardial function after myocardial infarction via up-regulation of PNUTS, 29/November/2016, 6.00 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What…

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Natural product Life-span extension therapy: N(1), N(11)-Diethylnorspermine, a spermine analog, may increase life span by suppressing mTOR pathway, 28/November/2016, 11.13 pm
Natural product Life-span extension therapy: N(1), N(11)-Diethylnorspermine, a spermine analog, may increase life span by suppressing mTOR pathway, 28/November/2016, 11.13 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What is known:  It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters” From research findings…

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