Ideas

Anticancer therapy: MiRNA-9600 increases the expression of DNA repair protein hMSH2 and inhibits cancer development via down regulation of its target gene, 25/November/2015, 11.56 am
Anticancer therapy: MiRNA-9600 increases the expression of DNA repair protein hMSH2 and inhibits cancer development via down regulation of its target gene, 25/November/2015, 11.56 am 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of DNA repair protein hMSH2. [easy_payment currency=”USD”]…

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Natural product therapy for glucose homeostasis and TIIDM: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 25/November/2015, 10.54 am
Natural product therapy for glucose homeostasis and TIIDM: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 25/November/2015, 10.54 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology,…

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Anti-telomerase cancer therapy: MiRNA-340 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 25/November/2016, 7.45 am
Anti-telomerase cancer therapy: MiRNA-340 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 25/November/2016, 7.45 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product Life-extension therapy: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/November/2016, 6.55 am
Natural product Life-extension therapy: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/November/2016, 6.55 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor Sprouty2 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,24/November/2015, 3.38 pm
Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor Sprouty2 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,24/November/2015, 3.38 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of metastasis suppressor Sprouty2. Thereby, it may…

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MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-1976 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 24/November/2016, 3.33 pm
MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-1976 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 24/November/2016, 3.33 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on…

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