Ideas

Natural product-derived combo therapy for ACAT1-overexpressing Human cancers: Curcumin and (6)-gingerol (6G) combo, one of the main components of Turmeric and Ginger, respectively, inhibits Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) expression, acetylation of Pyruvate dehydrogenase (PDH) and PDH phosphatase, pyruvate dehydrogenase complex (PDC) formation and tumor growth via down regulation of its target gene, 24/November/2015, 2.57 pm
Natural product-derived combo therapy for ACAT1-overexpressing Human cancers: Curcumin and (6)-gingerol (6G) combo, one of the main components of Turmeric and Ginger, respectively, inhibits Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) expression, acetylation of Pyruvate dehydrogenase (PDH) and PDH phosphatase, pyruvate dehydrogenase complex (PDC) formation and tumor growth via down regulation of its target gene, 24/November/2015, 2.57 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of…

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Molecular therapy for Metabolic disorders: MiRNA-152 increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 24/November/2016, 1.27 pm
Molecular therapy for Metabolic disorders: MiRNA-152 increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 24/November/2016, 1.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Public health relevance:  Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the…

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Anti-telomerase cancer therapy: MiRNA-1827 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 24/November/2016, 8.49 am
Anti-telomerase cancer therapy: MiRNA-1827 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 24/November/2016, 8.49 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor BTG2 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,23/November/2015, 6.06 am
Anti-metastasis therapy: MiRNA-9600 increases the expression of metastasis suppressor BTG2 and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,23/November/2015, 6.06 am 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of metastasis suppressor BTG2. Thereby, it may…

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Natural product therapy for glucose homeostasis and TIIDM: Areca nut extract or Arecoline increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 23/November/2015, 2.54 pm
Natural product therapy for glucose homeostasis and TIIDM: Areca nut extract or Arecoline increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 23/November/2015, 2.54 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology,…

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Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients:Persimmon tannin increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 23/November/2016, 2.51 pm
Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients:Persimmon tannin increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 23/November/2016, 2.51 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was…

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