Ideas

Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am
Natural product Life-span extension therapy: Plums (Prunus salicina L) extract increases life span by suppressing mTOR pathway through up regulation of its target gene, 22/November/2016, 6.10 am 150 150 Dr Boomi's Genom-2-Discovery Center

What is known: It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters” From research findings…

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Anti-telomerase cancer therapy: MiRNA-466g suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 21/November/2016, 11.22 pm
Anti-telomerase cancer therapy: MiRNA-466g suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 21/November/2016, 11.22 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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MiRNA-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: MiRNA-96 increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 21/November/2016, 8.10 pm
MiRNA-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: MiRNA-96 increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 21/November/2016, 8.10 pm 150 150 Dr Boomi's Genom-2-Discovery Center

[easy_payment]Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was…

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Natural product-based PD-1 pathway blockade for Human cancer therapy: γ-Bisabolene, found in Cardamom among others, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 21/November/2016, 11.17 am
Natural product-based PD-1 pathway blockade for Human cancer therapy: γ-Bisabolene, found in Cardamom among others, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 21/November/2016, 11.17 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Molecular therapy for Metabolic disorders: MiRNA-208-3p increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 21/November/2016, 11.04 am
Molecular therapy for Metabolic disorders: MiRNA-208-3p increases (LXR)-α expression, insulin-secreting cell mass and function via down regulation of its target genes, 21/November/2016, 11.04 am 150 150 Dr Boomi's Genom-2-Discovery Center

Significance of the study:  Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3)…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of tumor suppressor PTEN and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,21/November/2015, 10.38 am
Anti-metastasis therapy: MiRNA-9600 increases the expression of tumor suppressor PTEN and inhibits proliferation, invasion and metastasis of cancer cells via down regulation of its target gene,21/November/2015, 10.38 am 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor PTEN. Thereby, it may…

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