Ideas

Molecular therapy for Metabolic disorders: MiRNA-744 increases insulin-secreting cell mass and function via down regulation of its target genes, 19/November/2016, 10.33 am
Molecular therapy for Metabolic disorders: MiRNA-744 increases insulin-secreting cell mass and function via down regulation of its target genes, 19/November/2016, 10.33 am 150 150 Dr Boomi's Genom-2-Discovery Center

Significance of the study:  Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3)…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of PDCD4 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 19/November/2015, 10.15 am
Anti-metastasis therapy: MiRNA-9600 increases the expression of PDCD4 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 19/November/2015, 10.15 am 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of pro-apoptotic protein PDCD4. Thereby, it may…

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Natural product-based anti-ageing therapy: Berberine (BBR) , found in Phellodendron amurense and Berberis among others, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 18/November/2015, 11.18 pm
Natural product-based anti-ageing therapy: Berberine (BBR) , found in Phellodendron amurense and Berberis among others, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 18/November/2015, 11.18 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental…

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Small molecule-based therapy for Oropharyngeal candidiasis (OPC): OPN/Osteopontin increases IL-17R and antimicrobial peptide ß-defensin 3 (BD3, Defb3) expression and promotes resistance against infections caused by Candida albicans via up-regulation of its target gene, 18/November/2015, 10.55 pm
Small molecule-based therapy for Oropharyngeal candidiasis (OPC): OPN/Osteopontin increases IL-17R and antimicrobial peptide ß-defensin 3 (BD3, Defb3) expression and promotes resistance against infections caused by Candida albicans via up-regulation of its target gene, 18/November/2015, 10.55 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; and Department of Mucosal and Salivary Biology, King’s College…

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Life-extension therapy: Ossotide, a chemical compound known to promote bone formation, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/November/2016, 10.42 pm
Life-extension therapy: Ossotide, a chemical compound known to promote bone formation, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/November/2016, 10.42 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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Small Molecule therapy for glucose homeostasis and TIIDM: PGE2 (Prostaglandin-E2/ dinoprostone) increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 18/November/2015, 10.14 pm
Small Molecule therapy for glucose homeostasis and TIIDM: PGE2 (Prostaglandin-E2/ dinoprostone) increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 18/November/2015, 10.14 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology,…

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