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Ideas

February 22, 2017

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Tumor suppressor Menin (MEN1), responsible for multiple endocrine neoplasia type 1 syndrome, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/February/2017, 9.33 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
February 21, 2017

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of BTG2 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 21/February/2017, 11.16 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of […]
February 21, 2017

MiRNA-based therapy for Metastatic human tumors: MiR-382 decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 21/February/2017, 11.08 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen […]
February 21, 2017

Vitamin-based therapy for glucose homeostasis and TIIDM: γ-Tocotrienol , a form of Vitamin-E found in Elaeis guineensis and among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 21/February/2017, 10.57 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
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