Ideas

Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-9600 increases the expression of tumor suppressor p53 homologue TAp63 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/November/2016, 10.27 pm
Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-9600 increases the expression of tumor suppressor p53 homologue TAp63 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/November/2016, 10.27 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Significance: Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway is altered in about 80% of tumors. This study suggests a…

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Natural product-based therapy for Cardiomyopathy: Apple extract induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/November/2016, 2.24 pm
Natural product-based therapy for Cardiomyopathy: Apple extract induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/November/2016, 2.24 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp…

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Natural product therapy for glucose homeostasis and TIIDM: Oleic acid, found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 17/November/2015, 8.30 am
Natural product therapy for glucose homeostasis and TIIDM: Oleic acid, found in Safflower, olive, canola, Hazelnut, sunflower oils, Avacados, almond and sunflower among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 17/November/2015, 8.30 am 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology,…

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Natural product-based PD-1 pathway blockade for Human cancer therapy: Ginsenoside, isolated from Ginseng herb, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 17/November/2016, 7.18 am
Natural product-based PD-1 pathway blockade for Human cancer therapy: Ginsenoside, isolated from Ginseng herb, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 17/November/2016, 7.18 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on…

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Natural product therapy for Breast Cancer: Hyperoside, found in Drosera Rotundifolia and Common self-heal, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 17/November/2015, 6.55 am
Natural product therapy for Breast Cancer: Hyperoside, found in Drosera Rotundifolia and Common self-heal, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 17/November/2015, 6.55 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA…

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Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: miR-542-5p promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 17/November/2016, 6.34 am
Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: miR-542-5p promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 17/November/2016, 6.34 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose…

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