Ideas

Natural product-based PD-1 pathway blockade for Human cancer therapy: Eriocitrin, found in lemons , decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 12.58 pm
Natural product-based PD-1 pathway blockade for Human cancer therapy: Eriocitrin, found in lemons , decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 12.58 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Anti-metastasis therapy: MiRNA-9600 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 18/November/2015, 11.41 pm
Anti-metastasis therapy: MiRNA-9600 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 18/November/2015, 11.41 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:  The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of TPM1 (tropomyosin). Thereby, it may inhibit…

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Anti-telomerase cancer therapy: MiRNA-149 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 18/November/2016, 11.14 am
Anti-telomerase cancer therapy: MiRNA-149 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 18/November/2016, 11.14 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and…

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Natural product-based Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 18/November/2015, 7.04 am
Natural product-based Cardiac rejuvenation therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 18/November/2015, 7.04 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This…

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Natural product therapy for Breast Cancer: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara among others, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 18/November/2015, 6.07 am
Natural product therapy for Breast Cancer: Cucurbitacin D, found in Trichosanthes kirilowii (Gualou), Phormium tenaxm, and Luffa amara among others, increases the level of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 18/November/2015, 6.07 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA…

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Natural product therapy for tuberculosis: Curcumin, one of the main components of turmeric, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 17/November/2016, 10.58 pm
Natural product therapy for tuberculosis: Curcumin, one of the main components of turmeric, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 17/November/2016, 10.58 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was…

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