Ideas

August 7, 2017
Published by admin_auro at August 7, 2017
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Molecular therapy for glioblastoma: Artemisinin, the anti-parasitic drug,  inhibits the expression of JMJD6, impairs functioning of transcription elongation machinery, inhibits the proliferation of glioblastoma cells, suppresses tumor cell migration, reduces metastasis and prolongs survival via down regulation of its target gene, 7/August/2017, 9.32 pm

Introduction: What they say: A study from the Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Ohio, USA shows that “Transcription elongation factors […]
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August 7, 2017
Published by admin_auro at August 7, 2017
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Natural product-derived therapy for gynecologic cancers: Eriocitrin, one of the components of Lemons, inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 8/August/2017, 12/27 pm

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]
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August 6, 2017
Published by admin_auro at August 6, 2017
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The Ptpn2 pathway blockade enhances the efficacy of Cancer immunotherapy: Ivermectin, the anti-parasitic drug, inhibits the expression of protein tyrosine phosphatase PTPN2, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 6/August/2017, 11.01 pm

Introduction:What they say: A recent study from Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA; Broad Institute of Harvard and Massachusetts Institute of […]
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August 6, 2017
Published by admin_auro at August 6, 2017
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Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Sulforaphane, isolated from Broccoli, decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 6/August/2017, 10.52 pm

Introduction: What they say: A study from the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; […]
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