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Ideas

February 22, 2017

Natural product-derived antiviral therapy against HIV virus: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others,increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 22/February/2017, 10.31 am

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, […]
February 22, 2017

Molecular therapy for Bone disorders: Resistin, a pro-inflammatory cytokine, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 22/February/2017, 9.43 am

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]
February 22, 2017

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Tumor suppressor Menin (MEN1), responsible for multiple endocrine neoplasia type 1 syndrome, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/February/2017, 9.33 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
February 21, 2017

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of BTG2 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 21/February/2017, 11.16 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of […]
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