What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan- and healthspan-extension therapy: Methane-rich saline may increase life span via up-regulation of its target gene BubR1 and others
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, that methane-rich saline, by increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).
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Figure 1. Methane-rich saline may extend mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase
Figure 2. Methane-rich salilne as a longevity-promoting agent. It functions as a longevity-promoter by increasing the expression of BuBR1 and other longevity-promoting genes (fig 1).
Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, methyl-rich saline, either alone or in combination with other drugs,“ may be used to extend the lifespan of an individual (fig.2).
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $500#
Undisclosed mechanistic information: How methyl rich saline increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Lifespan- and healthspan-extension therapy: Methane-rich saline may increase life span via up-regulation of its target gene BubR1 and others, 10/May/2018, 7.37 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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