Mechanistic insights into how metformin aids in body weight control, energy homeostasis and TIIDM: Metformin, the widely used drug in the treatment of TIIDM, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/May/2018, 12.43 pm