Molecular therapy for TIIDM and Metabolic defects: Carvedilol (brand name: Coreg), used to treat high blood pressure and congestive heart failure, increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 23/December/2018, 11.19 pm