What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ), by Prof. Dominic J. Withers, Dr. Selman C, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product-based Lifespan extension therapy: Diosgenin, derived from Dioscorea, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, with detailed mechanistic insights, that Dioscorea, and its components, such as Diosgenin may extend the lifespan of humans. Diosgenin, by regulating the expression of its target gene, it may suppress the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Figure 1. Mechanistic insights into how Diosgenin may extend mammalian lifespan. Diosgenin functions as a longevity-promoter by decreasing the expression of p70S6 Kinase and increasing the expression of a number of longevity-promoting genes.
Figure 2. The chemical structures of Diosgenin, Diosgenin, derived from Dioscorea, extends lifespan through down regulation of p70 S6 kinase.
Figure 3. Diosgenin functions as a longevity promoter. Diosgenin, derived from Dioscorea or kokoro, extends lifespan through down regulation of p70 S6 kinase.
Figure 4. Figure 3. While genetic ablation of p70S6 Kinase extends lifespan, the studied presented here suggests that Diosgenin, by decreasing the expression of p70S6 Kinase, it increases insulin sensitivity, promotes resistance to bone, immune, and motor dysfunction, and extends lifespan.
Thus, a pharmacological formulation encompassing “Diosgenin or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).
Given the mechanistic basis as to how Diosgenin, derived from Dioscorea, can extend the lifespan of humans, its consumption can be increased.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Diosgenin decrease the expression of p70 S6 Kinase?
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References:
Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Diosgenin, derived from Dioscorea, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/July/2019, 11.10 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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