Sorry for the inconvenience,12/02/2015
Dear Colleagues We regret to inform you that our internet connection was disrupted on 12/02/2015. Therefore, we could not update any idea. Regards Dr L Boominathan PhD Founder Director-cum-Chief Scientist of GBMD
Mechanistic insight into tumorsuppression: BMP-6 increases the expression of tumor suppressor PDCD4 via down regulation of its target gene, 11/February/2015, 23.24
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorsuppression: BMP-6 increases the expression of tumor suppressor PDCD4 via down regulation of its target gene, 11/February/2015, 23.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that BMP-6, by decreasing the expression of its target gene, it may increase the expression of PDCD4. Thereby, it may […]
Molecular therapy for T2DM: β-catenin promotes gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 11/February/2014, 23.19
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >42] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. […]
AntagomiR-based therapy for pulmonary arterial hypertension: MIRNA-7 increases pulmonary arterial hypertension via down regulation of its target gene, 11/February/2015, 23.07
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests, for the first time, that MiRNA-7, by suppressing the expression of its target gene, it may increase pulmonary arterial hypertension. Thus, pharmacological formulations encompassing “MiRNA-7 inhibitors“ may be used to treat pulmonary arterial hypertension (PAH). Amount: $ 300* Undisclosed information: How MiRNA-7 increases pulmonary arterial hypertension To cite: Boominathan, AntagomiR-based therapy for […]
Molecular therapy for Inflammatory Bowel disease (IBD): PCBP2 preserves the functions of Beclin 1 and ATG5 and decreases tissue injury in inflammatory bowel disease (IBD) via down regulation of its target gene, 11/February/2015, 22.57
A study from Department of Medicine, University of Chicago, Chicago, Illinois, USA shows that “Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.” This study was published in the February 2, 2014 issue of J Clin Invest by Prof. Eugene B. Chang & Dr. Xiaorong Zhu. On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Molecular therapy for Inflammatory […]
Regenerative stem cell therapy for Myocardial Infarction: BMP4 inhibits myocardial function after myocardial infarction via down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 11/February/2015, 22.51
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the March 7 2013 issue of Nature by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative stem cell therapy for Myocardial Infarction: BMP4 inhibits myocardial function after myocardial infarction […]
