- A study from Division of Cellular and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, California, USA has reported that “miR-34/449 miRNAs are required for motile ciliogenesis by repressing..” This study was published in the 04 June 2014 Nature (IF: 38.597) by Prof. Lin He, Song Rui and others from from Division of Cellular and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, California, USA.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia): Tumor suppressor p53 increases Cilia length and number via up regulation of its target gene. This study suggests that p53, by increasing the expression of its target gene, it could ameliorate the respiratory dysfunction found in Primary cilia dyskinesia. Together, this study suggests that pharmacological formulations containing “p53-induced target gene or p53 inducers” can be used to treat Primary cilia dyskinesia.
- Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Mechanistic & Therapeutic insights into Motile Ciliogenesis & Respiratory dysfunction (Primary cilia dyskinesia):Tumor suppressor p53 increases Cilia length and number via up regulation of its target gene, 6/June/2014, 14.00, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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