The 1989 Nobel prize winner in Physiology/Medicine, Prof. Bishop JM, Qu J and others from G.W. Hooper Foundation, University of California at San Francisco, San Francisco, California 94143, USA has published a research paper in the 11 June 2012 J Cell Biol (I.F: >10) stating that “Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency.”
Based on this this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Anti-Cancer stem cell therapy: Tumor suppressor BMP4 inhibits the expression of Nucleostemin and reprogramming of somatic cells via up regulation of its target genes. This study suggests that BMP4, by suppressing the expression of Nucleoplasmin, it may increase the expression of a number of tumor suppressor genes. Thereby, it may inhibit self-renewal of ESEs. Thus, pharmacological formulations encompassing “BMP4 activators” may be used to target cancer stem cells and cure human cancer.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Anti-Cancer stem cell therapy: Tumor suppressor BMP4 inhibits the expression of Nucleostemin and reprogramming of somatic cells via up regulation of its target genes, 8/October/2014, 6.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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